New life for an old drug : the anthelmintic drug niclosamide inhibits 1 Pseudomonas aeruginosa quorum sensing 2 3 4
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چکیده
New life for an old drug: the anthelmintic drug niclosamide inhibits 1 Pseudomonas aeruginosa quorum sensing 2 3 4 Francesco Imperi, Francesco Massai, Cejoice Ramachandran Pillai, Francesca Longo, Elisabetta 5 Zennaro, Giordano Rampioni, Paolo Visca, Livia Leoni 6 7 8 1 Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, 9 Italy 10 2 Department of Biology, University Roma Tre, Rome, Italy 11 12 13 14 # Corresponding author. Mailing address: Department of Biology, University “Roma Tre”, Viale G. 15 Marconi 446, 00146 Rome, Italy. Phone: +39.6.5517.6318. Fax: +39.6.5517.6321. E-mail: 16 [email protected] 17 18 19 20 Running title: Niclosamide inhibits P. aeruginosa pathogenicity 21 22 23
منابع مشابه
New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing.
The need for novel antibacterial strategies and the awareness of the importance of quorum sensing (QS) in bacterial infections have stimulated research aimed at identifying QS inhibitors (QSIs). However, clinical application of QSIs identified so far is still distant, likely due to their unsuitability for use in humans. A promising way to overcome this problem is searching for anti-QS side acti...
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